Clinical heterogeneity brought about by tumor-initiating cells in primary liver cancer and the development of new therapeutic strategy by regulating microRNAs.

原发性肝癌肿瘤起始细胞带来的临床异质性及通过调控microRNA开发新的治疗策略。

• 批准号: 22591501
• 负责人: OHTSUKA Masayuki
• 金额: $ 2.91万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591501/
• 关键词: 癌源細胞; 肝細胞癌; 肝内胆管癌; 組織幹細胞; 表面マーカー; 分化; マイクロRNA; 原発性肝癌

Hepatocellular carcinomas could not be classified according to their phenotypic expression, since there were diverse patterns. In contrast, in intrahepatic cholangiocarcinomas, Notch2 was expressed in 56% of cases. Although Notch2 expression was inversely correlated with CD44 expression, this expression was significantly associated with c-Kit expression, suggesting that intrahepatic cholangiocarcinoma with positive Notch2 expression might be derived from hepatic progenitor cells. Survival among patients with positive Notch2 expression was significantly better than that among patients with negative Notch2 expression, indicating that Notch2 expression might have a connection with clinical behavior of intrahepatic cholangiocarcinomas. The expressions of MUC1 and MUC2, as well as p53, in intraductal papillary neoplasms of the bile duct were found to be different from those in conventional intrahepatic cholangiocarcinomas.

肝细胞癌不能根据其表型表达进行分类，因为有不同的模式。相比之下，在肝内胆管癌中，Notch 2在56%的病例中表达。虽然Notch 2表达与CD 44表达呈负相关，但这种表达与c-Kit表达显著相关，表明Notch 2阳性表达的肝内胆管癌可能来源于肝祖细胞。Notch 2表达阳性患者的生存率明显高于Notch 2表达阴性患者，提示Notch 2表达可能与肝内胆管癌的临床行为有关。MUC 1、MUC 2和p53在胆管内乳头状肿瘤中的表达与常规肝内胆管癌不同。

项目成果

CO Similarities and differences between intraductal papillary tumors of the bile duct with and without macroscopically visible mucin secretion

CO 具有和不具有肉眼可见粘蛋白分泌的胆管内乳头状肿瘤之间的异同

• 发表时间: 2011
• 期刊: Am Surg Pathol
• 作者: Ohtsuka M;Kimura F;Shimizu H;Yoshidome H;Kato A;Yoshitomi H;Furukawa K;Takeuchi D;Takayashiki T;Suda K;Takano S;Kondo Y;Miyazaki M
• 通讯作者: Miyazaki M

すべての胆管内乳頭状腫瘍は膵管内乳頭粘液性腫瘍の胆管カウンターパートか?

所有导管内乳头状肿瘤都是胰腺导管内乳头状粘液性肿瘤的胆道对应物吗？

• 发表时间: 2010
• 作者: 大塚将之;木村文夫;清水宏明;吉留博之;加藤厚;吉富秀幸;古川勝規;竹内男;高屋敷吏;須田浩介;高野重紹;宮崎勝
• 通讯作者: 宮崎勝

「肝内胆管、胆道、膵の腫瘍分類:WHOの新たな試みを含めて」肝内胆管・胆道 IPNB:粘液産生性、非産生性を含めて

“肝内胆管、胆道和胰腺的肿瘤分类：包括 WHO 的新尝试” 肝内胆管/胆道 IPNB：包括产生粘液和不产生粘液的肿瘤

• 发表时间: 2011
• 期刊: 肝胆膵
• 作者: 大塚将之;他
• 通讯作者: 他

CXCR4/CXCL12 expression profile is associated with tumor microenvironment and clinical outcome of liver metastases of colorectal cancer

• DOI: 10.1007/s10585-011-9433-5
• 发表时间: 2012-02-01
• 期刊: CLINICAL & EXPERIMENTAL METASTASIS
• 影响因子: 4
• 作者: Sakai, Nozomu;Yoshidome, Hiroyuki;Miyazaki, Masaru
• 通讯作者: Miyazaki, Masaru

粘液産生胆管腫瘍の臨床病理学的検討と治療方針

产粘蛋白胆管肿瘤的临床病理检查及治疗策略

• 发表时间: 2012
• 作者: 大塚将之;清水宏明;宮崎勝
• 通讯作者: 宮崎勝