Development of new refractory cancer treatment by remodelinginduction of cancer stroma

在肝内胆管癌（ICC）组织中，血管紧张素Ⅱ（Ang Ⅱ）受体AT-1和胰蛋白酶受体PAR-2在成纤维细胞和癌细胞中均有表达。此外，在ICC和肝星状细胞系中检测到AT-1受体表达。此外，血管紧张素Ⅱ引起的ICC和肝星状细胞的增殖能力和血管紧张素Ⅱ增加肝星状细胞的活化。这些反应可被血管紧张素Ⅱ受体阻断剂（ARB）所抑制。提示局部Ang Ⅱ生成系统影响ICC组织间质纤维化和肿瘤细胞增殖，ARB具有抗肿瘤和抗纤维化作用。

Angiotensin II (Ang II) receptor AT-1 and receptor of trypsin (PAR-2) were observed in fibroblasts and cancer cells in intrahepatic cholangiocarcinoma (ICC) tissue. In addition, AT-1 receptor expression was detected in ICC and hepatic stellate cell lines. Moreover, Ang II caused proliferative potential of ICC and hepatic stellate cells and Ang II increased activation of hepatic stellate cells. These reactionswere inhibited by the addition of Ang II receptor blocker (ARB). It was suggested thatlocal Ang II production system affect to interstitial fibrosis and proliferation of tumor cells in ICC tissue, and that there are anti-tumor and anti-fibrotic effects in ARB.