Evaluating of a new role of mesenchymal cells for immunity in pancreatic cancer and new standard for treatment of pancreatic cancer by using the immunity

评估间充质细胞在胰腺癌中免疫的新作用以及利用免疫治疗胰腺癌的新标准

• 批准号: 22591523
• 负责人: INOUE Shigetaka
• 金额: $ 2.83万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591523/
• 关键词: 膵癌; 腫瘍免疫; 間質細胞; 癌間質相互作用; 膵星細胞; マクロファージ

In pancreatic stellate cells (PSCs), we revealed that some subtypes of Toll LikeReceptor were found. Moreover, in the mRNA analysis for mRNA derived from a pancreatic cancer bulk organization, it became a bad prognosis in the FAS high quantity group, when the postoperative adjunct therapy was not being performed,. Furthermore, we revealed that PSCs subpopulation which expressed CD10 antigen, which shows specialization of a lymphocyte, has contributed to the malignant behaviors of a tumor. This evaluation for PSCs subtyping further progressed and found out a possibility that CD271 expression was related to a resistance factor to cancer cells, and a possibility that CD146 expression had controlled invasion of cancer cells. Moreover, macrophage preparative isolation from a tumor was performed by using magnetic-separation equipment, and it has expected to progress to the control mechanism elucidation of a cancer cell and stroma targetingspecific new medical treatment by the macrophages and mesenchymal cells in the future

在胰腺星状细胞（PSCs）中发现了Toll样受体的一些亚型，而且在胰腺癌组织来源的mRNA的mRNA分析中，FAS高量组在未进行术后辅助治疗时预后不良。此外，我们发现，PSCs亚群表达CD10抗原，这表明淋巴细胞的特化，有助于肿瘤的恶性行为。PSC分型的评价进一步进行，发现了CD271表达与癌细胞的抗性因子相关的可能性，以及CD146表达控制癌细胞侵袭的可能性。此外，通过使用磁分离设备从肿瘤中进行巨噬细胞的制备分离，并且期望在将来进展到通过巨噬细胞和间充质细胞靶向癌细胞和间质特异性新医学治疗的控制机制阐明

项目成果

CD10+ Pancreatic Stellate Cells Enhance the Progression of Pancreatic Cancer

• DOI: 10.1053/j.gastro.2010.05.084
• 发表时间: 2010-09-01
• 期刊: GASTROENTEROLOGY
• 影响因子: 29.4
• 作者: Ikenaga, Naoki;Ohuchida, Kenoki;Tanaka, Masao
• 通讯作者: Tanaka, Masao

CD271+ pancreatic stellate cells are correlated with prognosis of patients with pancreatic cancer and regulated by interaction

CD271胰腺星状细胞与胰腺癌患者的预后相关并受到相互作用的调节

• 发表时间: 2012
• 作者: Kenji Fujiwara;Kenoki Ohuchida;Koji Shindo;Shingo Kozono;Naoki Ikenaga;LinCui;Shinichi Aishima;Masafumi Nakamura;Kazuhiro Mizumoto;Yoshinao Oda;Masao Tanaka
• 通讯作者: Masao Tanaka

Fibroblasts expressing Podoplanin enhance the tumor progression

表达足平蛋白的成纤维细胞促进肿瘤进展

• 作者: Tanemura M;Nagano H;Taniyama K;Kamiike W;Mori M;Doki Y;Koji Shindo
• 通讯作者: Koji Shindo

CD10 positive pancreatic stellatecells enhance the progression of pancreatic cancer

CD10阳性胰腺星状细胞促进胰腺癌的进展

• 发表时间: 2011
• 作者: Naoki Ikenaga;Kenoki Ohuchida;Kazuhiro Mizumoto;Kenji Fujiwara;Shingo Kozono ;Takao Otsuka;Masafumi Nakamura;Masao Tanaka
• 通讯作者: Masao Tanaka

【膵がん・膵内分泌腫瘍の最近の動向】 膵がんの分子生物学的解析の現状(解説/特集)

[胰腺癌和胰腺内分泌肿瘤的最新动态]胰腺癌分子生物学分析的现状（解说/专题）

• 发表时间: 2011
• 作者: 大内田研宙;藤田逸人;水元一博;田中雅夫
• 通讯作者: 田中雅夫