Evaluating of a new role of mesenchymal cells for immunity in pancreatic cancer and new standard for treatment of pancreatic cancer by using the immunity

在胰腺星状细胞(PSCs)中，我们发现Toll LikeReceptor的某些亚型。此外，在胰腺癌肿瘤组织来源的mRNA的mRNA分析中，当术后不进行辅助治疗时，Fas高含量组预后不良。此外，我们还揭示了表达CD10抗原的PSCs亚群与肿瘤的恶性行为有关，CD10抗原表现为淋巴细胞的特化。对PSCs亚型的评估进一步发现，CD271的表达可能与癌细胞的耐药因素有关，CD146的表达可能控制了癌细胞的侵袭。此外，利用磁分离设备从肿瘤中进行了巨噬细胞的制备性分离，并有望在未来通过巨噬细胞和间充质细胞的靶向治疗来阐明肿瘤细胞和基质的调控机制。

In pancreatic stellate cells (PSCs), we revealed that some subtypes of Toll LikeReceptor were found. Moreover, in the mRNA analysis for mRNA derived from a pancreatic cancer bulk organization, it became a bad prognosis in the FAS high quantity group, when the postoperative adjunct therapy was not being performed,. Furthermore, we revealed that PSCs subpopulation which expressed CD10 antigen, which shows specialization of a lymphocyte, has contributed to the malignant behaviors of a tumor. This evaluation for PSCs subtyping further progressed and found out a possibility that CD271 expression was related to a resistance factor to cancer cells, and a possibility that CD146 expression had controlled invasion of cancer cells. Moreover, macrophage preparative isolation from a tumor was performed by using magnetic-separation equipment, and it has expected to progress to the control mechanism elucidation of a cancer cell and stroma targetingspecific new medical treatment by the macrophages and mesenchymal cells in the future