Antitumor effect of Chelated Endostatin

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We have assessed antitumor effect of chelated endostatin generating vector which secret chelated endostatin. We injected Lewis lung cancer cells (1×10^6) at the lateral abdominal wall of the BALBC mice. When the produced cancer nodule became 100mm^3in a volume, we started chemotherapy using endostatin transfection and/or anticancer agents (DTX, 5-FU). Then antitumor effect was assessed. Endostatin tranfection was performed by direct injection with plasmids surrounding the cancer nodule. Unfortunately we could not find any advantages of endostatin transfection accumulating anticancer agents.