Antitumor effect of Chelated Endostatin

我们评价了分泌螯合内皮抑素的螯合内皮抑素生成载体的抗肿瘤作用。我们将Lewis肺癌细胞(1×10~(^6))注射到BALBC小鼠的侧腹壁。当产生的癌结节体积达到100 mm^3时，开始使用内皮抑素转染剂和/或抗癌药(DTX、5-FU)进行化疗。并对其抗肿瘤作用进行评价。通过直接注射癌结节周围的质粒进行内皮抑素转基因。遗憾的是，我们没有发现内皮抑素转基因有任何优势，可以积聚抗癌药物。

We have assessed antitumor effect of chelated endostatin generating vector which secret chelated endostatin. We injected Lewis lung cancer cells (1×10^6) at the lateral abdominal wall of the BALBC mice. When the produced cancer nodule became 100mm^3in a volume, we started chemotherapy using endostatin transfection and/or anticancer agents (DTX, 5-FU). Then antitumor effect was assessed. Endostatin tranfection was performed by direct injection with plasmids surrounding the cancer nodule. Unfortunately we could not find any advantages of endostatin transfection accumulating anticancer agents.