Contribution of The Pro-inflammatory Cytokines and Aquaporin 1 & 4 in the Progression

促炎细胞因子和水通道蛋白 1 的贡献

• 批准号: 22591622
• 负责人: TACHIBANA Osamu
• 金额: $ 3万
• 依托单位: Kanazawa Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591622/
• 关键词: ラトケ嚢胞; 炎症性サイトカイン; アクアポリン; ホルモン受容体; サイトカイン; 炎症

Expression of water-channel aquoporin 1 and 4 in Rathke epithelium might stimulate to progression of cyst. Over-expression of androgen receptor in Rathke epithelium might induce proliferation with Rathke epithelium itself and inflammation in adenohypophysis. So aquaporin and androgen receptor might be novel target molecules totreat with symptomatic Rathke cleft cyst.

水通道蛋白1和4在Rathke上皮细胞中的表达可能促进了囊肿的进展。雄激素受体在Rathke上皮细胞中的过度表达可能导致Rathke上皮细胞本身的增殖和腺垂体的炎症。因此，水通道蛋白和雄激素受体可能是治疗症状性Rathke裂囊肿的新靶点。

项目成果

Surgical significance of anatomy for supra-sellar tumor in relation to arachnoid membrane and critical perforating branches on extended transsphenoidal surgery

扩大经蝶手术中鞍上肿瘤与蛛网膜和关键穿支相关的解剖学意义

• 作者: Nagane M;Nishikawa R et al.;Osamu Tachibana
• 通讯作者: Osamu Tachibana