The role of MMP and PAR in the pain of the work-related upper limb musculoskeletal disorders

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In work-related upper limb musculoskeletal disorders such as carpal tunnel syndrome and stenosing tenosynovitis, symptom duration correlated negativelywith pain severity and positively with disability. In pathological finding of tenosinovium, mast cell triptase which is an agonist of PAR2 was mainly express around vessels. Mast cell triptase correlated positively with cytokines such as TNF-α and IL-6. Weconsider that these factors were involved in pain severity. The expression of triptase decreased and the expression of VEGF increased over the course of the disease. Wethink that mast cell triptase plays an important role in the inflammation of the tenosynovium and pain severity.