The synergy between bFGF and bisphosphonate contributes to fracture healing

骨修复涉及一组复杂的调控信号通路，其控制新骨基质的形成和骨折部位受损骨基质的再吸收。结果表明，重组人成纤维细胞生长因子（rhFGF-2）能促进骨形成，增强骨的力学强度。rhFGF-2和ZA在最佳时间作为单剂量全身给药的协同作用对骨折修复有效，并显著增强骨融合。我们的研究结果表明，这种组合有利于骨愈合，并具有潜在的临床应用。

Bone repair involves a complex set of regulated signaling pathways that control the formation of new bone matrix and the resorption of damaged bone matrix at the fracture site. The resultssuggested that the recombinant human fibroblast growth factor (rhFGF-2) increased the bone formation and mechanical strength. The synergic effect of rhFGF-2 and ZA given systemically as a single dose at the optimal time was efficacious for fracture repair and significantly enhanced bone fusion. Our results suggest that this combination facilitates bone healing and has potential clinical application.