The synergy between bFGF and bisphosphonate contributes to fracture healing

骨修复涉及一系列复杂的调控信号通路，这些信号通路控制新骨基质的形成和骨折部位受损骨基质的吸收。结果表明，重组人成纤维细胞生长因子-2可增加骨形成和机械强度。系统地在最佳时间单次给药对骨折修复和骨融合有明显的促进作用，两者具有协同作用。我们的结果表明，这种组合促进了骨愈合，具有潜在的临床应用价值。

Bone repair involves a complex set of regulated signaling pathways that control the formation of new bone matrix and the resorption of damaged bone matrix at the fracture site. The resultssuggested that the recombinant human fibroblast growth factor (rhFGF-2) increased the bone formation and mechanical strength. The synergic effect of rhFGF-2 and ZA given systemically as a single dose at the optimal time was efficacious for fracture repair and significantly enhanced bone fusion. Our results suggest that this combination facilitates bone healing and has potential clinical application.