Distinguishing the Proapoptotic and Antiresorptive Functions of Bisphosphonates inMurine Osteoclasts

区分双膦酸盐在小鼠破骨细胞中的促凋亡和抗吸收功能

• 批准号: 22591679
• 负责人: OHSHIMA Yasushi
• 金额: $ 2.91万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591679/
• 关键词: 骨; 軟骨代謝学; 骨・軟骨代謝学; リセドロネート; 破骨細胞; 細胞骨格; Akt

Nitrogen-containing bisphosphonates are one of the most successful therapeutics for osteoporosis. The aim of this study was to elucidate the functional mechanism of nitrogencontaining bisphosphonates. This study indicates that the antiresorptive effect of nitrogen-containing bisphosphonates is mainly mediated by the suppression of the bone-resorbing activity of osteoclasts and not by the induction of osteoclast apoptosis.

含氮双膦酸盐是治疗骨质疏松症最成功的药物之一。本研究的目的是阐明含氮双膦酸盐的作用机制。这项研究表明，含氮双膦酸盐的抗骨吸收作用主要是通过抑制破骨细胞的骨吸收活性介导的，而不是通过诱导破骨细胞凋亡。

项目成果

Regulation of RANKL‐induced osteoclastogenesis by TGF‐β through molecular interaction between Smad3 and Traf6

• DOI: 10.1002/jbmr.357
• 发表时间: 2011-07
• 期刊: Journal of Bone and Mineral Research
• 影响因子: 6.2
• 作者: T. Yasui;Y. Kadono;Masaki Nakamura;Y. Oshima;Takumi Matsumoto;Hironari Masuda;J. Hirose;Y. Omata;H. Yasuda;T. Imamura;Kozo Nakamura;Sakae Tanaka

Erk and Akt pathways are modulated by risedronate and reciprocally regulate apoptosis and activity of osteoclasts: insight into in vivo mechanism of action

Erk 和 Akt 通路受利塞膦酸盐调节并相互调节破骨细胞的凋亡和活性：深入了解体内作用机制

• 发表时间: 2010
• 作者: Takumi Matsumoto;Yuho Kadono;Tetsuro Yasui;Hironari Masuda;Kozo Nakamura;Stakae Tanaka.
• 通讯作者: Stakae Tanaka.

Segregation of pro-apoptotic and anti-resoptive functions of risedronate in vivo

利塞膦酸盐体内促凋亡和抗反应功能的分离

• 发表时间: 2010
• 作者: Takumi Matsumoto;Yuho KadonoTetsuroYasui;Hironari Masuda;Kozo Nakamura;Stakae Tanaka..
• 通讯作者: Stakae Tanaka..

Distinguishing the proapoptotic and antiresorptive functions of risedronate in murine osteoclasts: Role of the akt pathway and the ERK/Bim axis

• DOI: 10.1002/art.30646
• 发表时间: 2011-12-01
• 期刊: ARTHRITIS AND RHEUMATISM
• 作者: Matsumoto, Takumi;Nagase, Yuichi;Tanaka, Sakae
• 通讯作者: Tanaka, Sakae

Regulation of Apoptosis and Function of Osteoclasts by Bcl-2 Family Proteins

Bcl-2 家族蛋白对破骨细胞凋亡和功能的调节

• 发表时间: 2010
• 作者: Kuboniwa;et al.;田中栄
• 通讯作者: 田中栄