Involvement of receptor for advanced glycation end products for hyperglycemia-induced aggravation of white matter damage by cerebral ischemia

晚期糖基化终末产物受体参与高血糖引起的脑缺血白质损伤加重

• 批准号: 22591720
• 负责人: NAKAO Shinichi
• 金额: $ 2.83万
• 依托单位: Kinki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591720/
• 关键词: 全脳虚血; 高血糖; 脳白質; 活性酸素; 最終糖化産物; 脳灰白質; HMGB1; RAGE; 脳虚血

Global cerebral ischemia was induced by 5 min of cardiac arrest and resuscitation (CAR) in male rats with or without acute glucose administration (2g/kg i.p.). Two weeks after the CAR, the brain was extracted and brain slices were prepared. Microglial activation, neuronal and axonal injuries, and RAGE (receptor for advanced glycation end products) expression were detected in the hippocampal CA1 region in both groups, i.e., a glucose-administered group and a vehicle-administered group, but the statistically significant differences of those were not detected between the two groups. Neurologic deficit scores, which can detect functional damage in the brain, were similar in the both groups. I assume that the reason is due to the fact that sample size was not enough or that CAR alone caused rather hyperglycemia.

通过对雄性大鼠进行 5 分钟的心脏骤停和复苏 (CAR)，在有或没有急性葡萄糖注射（2g/kg i.p.）的情况下诱导全脑缺血。 CAR 两周后，提取大脑并制备脑切片。两组（即葡萄糖给药组和载体给药组）的海马CA1区均检测到小胶质细胞活化、神经元和轴突损伤以及RAGE（晚期糖基化终末产物受体）表达，但两组之间未检测到这些差异的统计学显着性。神经功能缺陷评分（可以检测大脑功能损伤）在两组中相似。我认为原因是样本量不够或者单独使用CAR引起了相当高的血糖。

项目成果

White Matter Injury in Stroke and CNS Disease (Chapter 10: Global ischemic white matter injury in patients)

中风和中枢神经系统疾病中的白质损伤（第 10 章：患者全身缺血性白质损伤）

• 发表时间: 2013
• 作者: Shibukawa Y;Tomioka T;他;中尾慎一;中尾慎一;中尾慎一;Nakao S;Shinichi Nakao;上原圭司;中尾 慎一;Carmichael Jr S (Chapter 10: Nakao S and Xu Y)
• 通讯作者: Carmichael Jr S (Chapter 10: Nakao S and Xu Y)

痛みと長期増強(long-term potentiation)

疼痛和长时程增强

• 发表时间: 2011
• 期刊: ペインクリニック
• 作者: Iwamoto T;Takasugi Y;Higashino H;Ito H;Koga Y;Nakao S;中尾慎一
• 通讯作者: 中尾慎一

洗浄回収処理後の赤血球機能および代謝低下への赤血球若返り液(AIS液)添加の影響

添加红细胞再生液（AIS液）对洗涤恢复处理后红细胞功能及代谢下降的影响

• 发表时间: 2010
• 作者: Shibukawa Y;Tomioka T;他;中尾慎一;中尾慎一;中尾慎一;Nakao S;Shinichi Nakao;上原圭司
• 通讯作者: 上原圭司

Antinociceptive action of carbamazepine on thermal hypersensitive pain at spinal level in a rat model of adjuvant-induced chronic inflammation

卡马西平对佐剂诱导的慢性炎症大鼠模型脊髓热敏性疼痛的镇痛作用

• 发表时间: 2011
• 期刊: J Anesth
• 影响因子: 2.8
• 作者: Iwamoto T;Takasugi Y;Higashino H;Ito H;Koga Y;Nakao S
• 通讯作者: Nakao S

全身麻酔薬の中枢神経作用部位

全身麻醉药的中枢神经系统作用部位

• 发表时间: 2010
• 期刊: 医学のあゆみ
• 作者: 中尾慎一;新宮興
• 通讯作者: 新宮興