The mechanisms of immunosuppression and organ dysfunctions following surgical stress and its modulation.

本研究的目的是探讨外科应激导致免疫抑制和器官功能障碍的机制，并制定其调控策略。创伤-出血(T-H)后，血浆肿瘤坏死因子-α、IL-6和HMGB1水平升高。血浆AST和ALT浓度在T-H后也升高。血栓调节蛋白(TM)可改善血浆细胞因子和HMGBl浓度。肝脏损伤也有所改善。TM对外科应激患者可能是一种有益的治疗方法。

The purposes of this study were to investigate the mechanisms of surgical stress induced immunosupPression and organ dysfunction and to develop the strategy of its regulation. After trauma-hemorrhage (T-H), plasma levels of TNF-α, IL-6, and HMGBl increased. Plasma AST and ALT concentrations also increased after T-H. Thrombomodulin (TM) treated improved plasma cytokines and HMGBl concentrations. Liver injury also improved. TM may be a beneficial treatment for surgical stressed patients.