Elucidation of Signal Networks to Stress in Renal Cell Carcinoma by Proteomic Analysis

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We found some intracellular molecules in human renal cell carcinoma(RCC) cells which expressed or activated by hypoxia conditions using proteome analyses. These molecules were thought to act critical roles in the intracellular signal pathways to gain the resistance to tyrosine kinase inhibitors (TKI) targeting angiogenesis, which were mainstay of treatment for human RCC. One of these molecules acts to regulate glucoseuptake, and glucose uptake was speculated to be the index to resistance to TKI treatment. Actually, we found that the uptake of glucose in human RCC evaluated by FDG PET/CT could predict the response of RCC to TKI treatment.