Association between single nucleotide polymorphism of beta2-Adrenergic receptor gene and pelvic floor muscle function in POP and/or SUI patients

盆腔器官脱垂(POP)和/或压力性尿失禁患者的盆底肌(PFM)功能较低。我们推测，β2-肾上腺素能受体基因单核苷酸多态性可能与盆底肌功能有关。我们开发了一套独创的系统，它可以通过触摸传感器阵列记录阴道内压力，并通过阴道内探头评估PFM的运动。我们还建立了用TaqMan方法检测β2-肾上腺素能受体基因单核苷酸多态的实时荧光定量PCR方法。需要对POP和/或SUI病例的数量进行进一步研究才能证实我们的假设。

Patients with pelvic organ prolapse (POP) and/or stress urinaryincontinence have lower pelvic floor muscle (PFM) function. We hypothesized that single nucleotide polymorphism of beta 2-Adrenergic receptor gene could be associated with pelvic floor muscle function. We have developed our original system which can record the intra-vaginal pressure by touch sensor array and PFM movement by evaluation using an intravaginal probe. We have also established the methods which can detect single nucleotide polymorphism of beta 2-Adrenergic receptor gene by TaqMan methods using real time PCR. Further studies with number of POP and/or SUI cases are required to confirm ourhypothesis.