Association between single nucleotide polymorphism of beta2-Adrenergic receptor gene and pelvic floor muscle function in POP and/or SUI patients

POP和/或SUI患者β2-肾上腺素受体基因单核苷酸多态性与盆底肌功能的关联

• 批准号: 22591795
• 负责人: SHISHIDO Keiichi
• 金额: $ 2.91万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22591795/
• 关键词: ss2 受容体; 女性骨盤底; 遺伝子多型; 骨盤底筋; β2受容体; 骨盤臓器脱

Patients with pelvic organ prolapse (POP) and/or stress urinaryincontinence have lower pelvic floor muscle (PFM) function. We hypothesized that single nucleotide polymorphism of beta 2-Adrenergic receptor gene could be associated with pelvic floor muscle function. We have developed our original system which can record the intra-vaginal pressure by touch sensor array and PFM movement by evaluation using an intravaginal probe. We have also established the methods which can detect single nucleotide polymorphism of beta 2-Adrenergic receptor gene by TaqMan methods using real time PCR. Further studies with number of POP and/or SUI cases are required to confirm ourhypothesis.

盆腔器官脱垂（POP）和/或压力性尿失禁患者的盆底肌功能较低。我们推测β 2-肾上腺素能受体基因单核苷酸多态性可能与盆底肌功能相关。我们已经开发了我们的原始系统，可以记录阴道内的压力，通过触摸传感器阵列和PFM运动的评估使用阴道内探头。建立了β 2-肾上腺素能受体基因单核苷酸多态性的真实的时间PCR检测方法。需要进一步研究POP和/或SUI病例的数量来证实我们的假设。