Investigation for the molecular mechanism of the association between obesity and endometrial cancer

我们证实了日本绝经后子宫内膜癌患者瘦素和瘦素/脂联素（L/A）比值升高的存在。体重指数正常化后，瘦素和L/A比值与子宫内膜癌发展风险增加有关，这表明瘦素和L/A比值是子宫内膜癌风险的预测因子，独立于肥胖。瘦素治疗子宫内膜癌细胞后，CyclinD1表达升高，JAK/STAT通路主要与CyclinD1表达相关。雌激素和瘦素协同刺激子宫内膜癌细胞增殖。

We demonstrated the presence of elevated leptin and leptin/adiponectin (L/A) ratios in Japanese postmenopausal endometrial cancer patients. The leptin and L/A ratios were associated with an increased risk of endometrial cancer development after the normalization of the BMI, suggesting that the leptin and L/A ratio is a predictor of endometrial cancer risk, independent of obesity. Elevated Cyclin D1 expression was observed after leptin treatment for endometrial cancer cells and JAK/STAT pathway was mainly associated for the expression of CyclinD1. Estrogen and leptin stimulated endometrial cancer cell proliferation in a coordinated manner.