Investigation for the molecular mechanism of the association between obesity and endometrial cancer

我们证明了日本绝经后子宫内膜癌患者存在瘦素和瘦素/脂联素（L/A）比值升高。瘦素和L/A比值与BMI正常化后子宫内膜癌发生风险增加相关，表明瘦素和L/A比值是子宫内膜癌风险的预测因子，与肥胖无关。CyclinD 1在瘦素作用下表达增加，JAK/STAT信号通路主要与CyclinD 1的表达相关。雌激素和瘦素协同刺激子宫内膜癌细胞增殖。

We demonstrated the presence of elevated leptin and leptin/adiponectin (L/A) ratios in Japanese postmenopausal endometrial cancer patients. The leptin and L/A ratios were associated with an increased risk of endometrial cancer development after the normalization of the BMI, suggesting that the leptin and L/A ratio is a predictor of endometrial cancer risk, independent of obesity. Elevated Cyclin D1 expression was observed after leptin treatment for endometrial cancer cells and JAK/STAT pathway was mainly associated for the expression of CyclinD1. Estrogen and leptin stimulated endometrial cancer cell proliferation in a coordinated manner.