The mechanism of acquisition of metastatic and invasive capacityin endometrial cancer cell

我们从对子宫内膜癌干细胞启示增加的基因簇中选择了SPARC（分泌酸性和富含半胱氨酸的蛋白），并对其进行了分析。SPARC在正常子宫内膜中不表达，但在子宫内膜癌，特别是在子宫体低分化腺癌中高表达。这些数据表明，SPARC与肿瘤基质形成的微环境和迁移能力有关。

We select SPARC (secreted protein acidic and rich in cystein) from the gene clusters which revelation is increasing to the endometrial cancer stem cell, and analyzed it. There is no-expression of SPARC in normal endometrium, but highly expressed in the endometrial cancer, especially in poorly differentiated adenocarcinoma of uterine corpus. These data showed that SPARC was associated with micro-environment of tumor-stroma formation and the migration capability.