The Change of Heat Shock Response in the Aging Inner Ear

在老龄化社会中，老年性听力损失是降低老年人生活质量的因素之一。在这项研究中，我们检测了衰老相关基因在老年性耳聋小鼠模型内耳中的表达，因为衰老相关基因参与了老年性耳聋的发展。我没有改变与衰老相关的基因，在研究中使用了(HSF1缺陷小鼠，TSOD小鼠)小鼠表现出类似老年性耳聋的症状。而衰老的TSOD小鼠IGF-1基因表达降低。其他类型基因的表达发生了变化。我们正在分析衰老后基因表达变化的原因。

In an aging society, age-related hearing loss is one of the factors to reduce the QOL of the elderly. In the study, we examined gene expression in inner ear of age-related deafness mouse model, as the senescence-associated genes are involved in the development of presbycusis. I was no change in the gene associated with aging in the study using (HSF1-deficient mice, TSOD mouse) mice exhibit symptoms similar to presbycusis. However, the expression of IGF-1 gene decreased in aging TSOD mouse. The expression of the other kinds of gene was changed. We are analyzing the reason for the change of the gene expression after aging.