Analysis of infectious tolerance in chronic middle ear inflammation with nontypeable Haemophilus influenzae

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Nontypeable Haemophilus influenzae (NTHi) is considered a major pathogen underlying middle ear infection. This study aimed to investigate the dynamics of IL-17 in chronic otitis media induced by NTHi in Balb/c mice. NTHi was injected into the tympanic bulla with Eustachian tubal obstruction. Middle ear effusions and tissues were collected at day 3, 14, 2 month after injection. The concentration of IL-17 in middle ear effusions eleveated significantly during experiments when compared to control. IL-17 producing ・・ T cells and Th17 cells were also increased up to 6 months in the middle ear. Based on these findings, IL-17 producing T cells existed in chronic state of otitis media, and may play some role for modification of chronic inflammation in the middle ear.