Elucidation of the pathogenesis and the onset of eosinophilic rhinosinusitis by airborne microorganisms (fungi, Staphylococcus aureus)

在我们的临床研究中，我们发现鼻息肉中的局部总IgE和抗原（真菌、螨和SE）特异性IgE与CRSwNP和AFRS的局部嗜酸性炎症有关。在我们的体外研究中，我们还发现链格孢菌的天冬氨酸蛋白酶通过PAR-2介导诱导气道上皮细胞的细胞因子产生和钙反应。此外，我们还发现，无论是上皮细胞和浸润的嗜酸性粒细胞在ECRS中的PAR-2的表达显着上调。

In our clinical study, we found that local total IgE and antigen (fungi, mites and SEs)-specific IgEs in nasal polyps are related to local eosinophilic inflammation of CRSwNP and AFRS. In our vitro study, we also found that Aspartate proteases from Alternariainduce cytokine production and calcium responsein airway epithelium that is mediated through PAR-2.. Furthermore, we also found that both the epithelium and the infiltrating eosinophils in the ECRS showed significant upregulation of the expression of PAR-2.