Comprehensive analysis of the thyroid undifferentiated conversion by using a mass spectrometry

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It was revealed that one type of Sphingomyelin and two types of phosphatidylcholine in thyroid papillary carcinoma are more expressed as compared with normal thyroid tissue by using a mass spectrometry. Sphingomyelin or phosphatidylcholine is a type of phospholipid, and it is classified by each lipid acid constituting each phospholipid.But it is not known whether there is a biological meaningor a characteristic of the cancer due to the differences in fatty acid.Ten types of lipid were expressed in undifferentiated carcinoma more than in normal thyroid tissue. It is generally known that undifferentiated carcinoma has much gene mutation as compared with papillary carcinoma. Therefore each difference in lipid distribution was expected to be large in undifferentiated carcinoma. But in fact the difference in undifferentiated carcinoma was smaller than that in papillarycarcinoma.