Roles of hypothalamic S6 kinase on diabetes

(1)db/db组小鼠肝脏中LKB1的表达明显低于对照组。LKB1在db/db小鼠肝脏中的表达载体可改善血糖控制。(2)表达载体抑制下丘脑弓状核中S6激酶上游调节因子PTEN，可抑制摄食量和体重增加，但这种作用因过度摄食而减弱。在弓状核抑制PTEN可以改善胰岛素敏感性，而不依赖于体重。

(1) The expression of LKB1 in the liver of db/db mouse was decreased compared to the control mouse. LKB1 rescue in db/db mouse liver by expression vector improved glycemic control.(2) Inhibition of PTEN, the upstream regulator of S6 kinase, in the hypothalamic arcuate nucleus by an expression vector suppressed food intake and body weight gain, but this effect was blunted by overfeeding. PTEN inhibition in the arcuate nucleus improved insulin sensitivity independent to body weight.