R oleofadipocyte-pcificmRNAregulatorysysteminthecontrol ofinsulin-mediatedglesucosemetabolism

脂肪细胞在控制胰岛素敏感性中起重要作用。我们之前已经证明，一种rna结合蛋白Hzf在脂肪组织中特异性表达，是脂肪细胞正常功能所必需的，从而有助于胰岛素介导的葡萄糖代谢的调节。我们在这里研究了Hzf在脂肪细胞中发挥作用的详细分子机制，并表明Hzf与另一种rna结合蛋白HuR相关。这些蛋白通过转录后机制共同调控基因表达，这是脂肪细胞功能所必需的。

Adipocytes play essential roles in controlling the insulin sensitivity. We have previously shown that an RNA-binding protein Hzf is specifically expressed inadipose tissue and required for proper adipocyte functions thereby contributing to theregulation of insulin-mediated glucose metabolism. We here investigate the detailed molecular mechanism by which Hzf functions in adipocytes and show that Hzf associateswith another RNA-binding protein HuR. These proteins cooperate in the regulation of geneexpression through post-transcriptional mechanism, which is required for the adipocytefunctions.