R oleofadipocyte-pcificmRNAregulatorysysteminthecontrol ofinsulin-mediatedglesucosemetabolism

脂肪细胞特异性mRNA调节系统在控制胰岛素介导的葡萄糖代谢中的作用

• 批准号: 22790879
• 负责人: SUGIMOTO Masataka
• 金额: $ 2.58万
• 依托单位: National Center for Geriatrics and Gerontology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790879/
• 关键词: RNA結合タンパク質; 脂肪細胞; 翻訳

Adipocytes play essential roles in controlling the insulin sensitivity. We have previously shown that an RNA-binding protein Hzf is specifically expressed inadipose tissue and required for proper adipocyte functions thereby contributing to theregulation of insulin-mediated glucose metabolism. We here investigate the detailed molecular mechanism by which Hzf functions in adipocytes and show that Hzf associateswith another RNA-binding protein HuR. These proteins cooperate in the regulation of geneexpression through post-transcriptional mechanism, which is required for the adipocytefunctions.

脂肪细胞在调节胰岛素敏感性中起重要作用。我们先前已经证明RNA结合蛋白Hzf在脂肪组织中特异性表达，并且是脂肪细胞正常功能所必需的，从而有助于胰岛素介导的葡萄糖代谢的调节.我们在此研究了Hzf在脂肪细胞中发挥作用的详细分子机制，并表明Hzf与另一种RNA结合蛋白HuR相关。这些蛋白质通过转录后机制协同调控基因表达，这是脂肪细胞功能所必需的。

项目成果

Post-transcriptional regulation of the p53 tumor suppressor

p53肿瘤抑制因子的转录后调控

• 发表时间: 2010
• 作者: Nakamura;H.;Kawagishi;H.;Watanabe;A;Maruyama;M.;Sugimoto;M
• 通讯作者: M

RNA-binding protein HuR suppressescellular lifespan by repressing the translation of ARF mRNA

RNA结合蛋白HuR通过抑制ARF mRNA的翻译来抑制细胞寿命

• 发表时间: 2011
• 作者: Kawagishi;H. and Sugimoto;M
• 通讯作者: M

Post-transcriptional regulation of the p53 pathway

p53 通路的转录后调控

• 发表时间: 2010
• 作者: Sugimoto;M;杉本昌隆
• 通讯作者: 杉本昌隆

Cooperative Role of the RNA-Binding Proteins Hzf and HuR in p53 Activation

• DOI: 10.1128/mcb.01424-10
• 发表时间: 2011-05-01
• 期刊: MOLECULAR AND CELLULAR BIOLOGY
• 影响因子: 5.3
• 作者: Nakamura, Hideaki;Kawagishi, Hiroyuki;Sugimoto, Masataka
• 通讯作者: Sugimoto, Masataka

HuR maintains replicative lifespan by repressing ARF tumor suppressor

HuR 通过抑制 ARF 肿瘤抑制因子维持复制寿命

• 发表时间: 2011
• 作者: Kawagishi;H.;Nakamura;H.;Tsugawa;T. and Sugimoto;M
• 通讯作者: M