The study of feeding and metabolism regulated by nesfatin-1-oxytocin-POMC system

nesfatin-1-催产素-POMC系统调控摄食与代谢的研究

• 批准号: 22790887
• 负责人: MAEJIMA Yuko
• 金额: $ 2.58万
• 依托单位: Jichi Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790887/
• 关键词: 内分泌学; オキシトシン; 弓状核; プロオピオメラノコルチン; ネスファチン; POMC; 摂食; プロオピオメラノコルチン(POMC); 代謝; 室傍核; 孤束核

The activation of proopiomelanocortin neurons in Nucleus tractus solitarius(NTS) by oxytocin has been reported. However, the effect of oxytocin on POMC neurons in arcuate nucleus(ARC) has not been examined yet. This study clarified that oxytocin is physiological anorectic peptides, and activates ARC POMC neurons, as well as NTS POMC neurons. It is also suggested that oxytocin could activated ARC POMC neurons even in the leptin resistant animal model.

催产素对孤束核(NTS)阿片黑素皮质素原神经元的激活作用已有报道。然而，催产素对弓状核(ARC)POMC神经元的影响尚未见报道。本研究阐明催产素是一种生理性厌食多肽，可激活ARC POMC神经元和NTS POMC神经元。在瘦素抵抗的动物模型中，催产素也能激活ARC POMC神经元。

项目成果

Insulin suppresses ghrelin-induced calcium signaling in neuropeptide Y of the hypothalamic arcuate nucleus

胰岛素抑制下丘脑弓状核神经肽 Y 中生长素释放肽诱导的钙信号传导

• 发表时间: 2011
• 期刊: Aging(Albany NY)
• 作者: Maejima Y.;Kohno D.;Iwasaki Y.;Yada T.
• 通讯作者: Yada T.

Nesfatin-1-regulated oxytocinergic signalling in the paraventricular nucleus causes anorexia via melanocortin pathway

Nesfatin-1 调节室旁核催产素信号通过黑皮质素途径引起厌食

• 发表时间: 2010
• 作者: 佐藤貴弘;中村祐樹;井田隆徳;御船弘治;寒川賢治;児島将康;Yuko Maejima
• 通讯作者: Yuko Maejima

Feeding Regulation by Oxytocin of Hypothalamic Paraventricular Nucleus

下丘脑室旁核催产素的摄食调节

• 发表时间: 2010
• 作者: 佐藤貴弘;中村祐樹;御船弘治;井田隆徳;寒川賢治;児島将康;佐藤貴弘;前島裕子
• 通讯作者: 前島裕子

Peripheral oxytocin treatment ameliorates obesity by reducing food intake and visceral fat mass

• DOI: 10.18632/aging.100408
• 发表时间: 2011-12-01
• 期刊: AGING-US
• 影响因子: 5.2
• 作者: Maejima, Yuko;Iwasaki, Yusaku;Yada, Toshihiko
• 通讯作者: Yada, Toshihiko

視床下部室傍核Nesfatin-1-Oxytocinによる摂食調節と病態的意義

Nesfatin-1-催产素对下丘脑室旁核摄食的调节及其病理意义

• 发表时间: 2011
• 作者: Ida T;Miyazato M;Lin XZ;Kaiya H;Sato T;Nakahaza K;Murakami N;Kangawa K;Kojima M.;前島裕子
• 通讯作者: 前島裕子