What is the true remission in rheumatoid arthritis?

什么是类风湿性关节炎的真正缓解？

• 批准号: 22790937
• 负责人: TAMAI Mami
• 金额: $ 2.58万
• 依托单位: Nagasaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22790937/
• 关键词: リウマチ学; 関節リウマチ; 真の寛解; 疾患活動性; 関節MRI骨髄浮腫

To investigate the true remission in rheumatoid arthritis(RA), we studied very early RA with poor prognosis factors. Treatment with synthetic disease-modifying anti-rheumatic drugs reduced RA progression from undifferentiated arthritis. Significant improvement in MRI-proven bone edema may be associated with protection against structural damage(rs=0. 65, p<0. 05) and persistent remission during 12 months in very early RA patients managed using the tight control approach. The frequency of peripheral blood regulatory T cells in patients with RA negatively correlated with disease activity score, CRP and ESR. The regulatory T cell frequency of patients with RA in remission was similar to that of healthy controls.

为了探讨类风湿关节炎(RA)的真正缓解情况，我们研究了预后不良的早期RA。使用合成的抗风湿病药物治疗可以减少未分化关节炎的RA进展。MRI证实的骨水肿的显著改善可能与对结构性损伤的保护有关(rS=0。65，p&lt；0。05)，使用严格控制方法管理的极早期RA患者在12个月内持续缓解。RA患者外周血调节性T细胞频率与疾病活动性评分、C反应蛋白、血沉呈负相关。RA缓解期患者调节性T细胞频率与正常对照组相似。

项目成果

Magnetic resonance imaging of wrist and finger joints distinguishes secondary Sjogren' s syndrome with rheumatoid arthritis from primary Sjogren' s syndrome with articular manifestations

腕部和手指关节的磁共振成像可区分伴有类风湿性关节炎的继发性干燥综合征和具有关节表现的原发性干燥综合征

• 发表时间: 2011
• 期刊: Clin Exp Rheumatol
• 影响因子: 3.7
• 作者: Iwamoto N;Kawakami A;Tamai M;Arima K;Nakamura H;Kawashiri SY;Kita J;Okada A;Koga T;Kamachi M;Yamasaki S;Ichinose K;Ida H;Origuchi T;Uetani M;Eguchi K.
• 通讯作者: Eguchi K.

Delayed treatment with tumor necrosis factor inhibitors in incomplete responders to synthetic disease-modifying anti-rheumatic drags shows an excellent effect in patients with very early rheumatoid arthritis with poor prognosis factors

对合成缓解病情抗风湿药物不完全反应的患者延迟使用肿瘤坏死因子抑制剂治疗，对于预后不良的极早期类风湿性关节炎患者显示出良好的效果

• DOI: 10.1007/s10165-011-0511-y
• 发表时间: 2011
• 期刊: Mod Rheumatol
• 影响因子: 2.2
• 作者: Kita J;Tamai M(筆頭共著者);ArimaK;Nakashima Y;Suzuki T;Kawashiri SY;Okada A;Koga T;Yamasaki S;Nakamura H;Origuchi T;Aramaki T;Nakashima M;Fujikawa K;Tsukada T;Ida H;Aoyagi K;Uetani M;Eguchi K;Kawakami A
• 通讯作者: Kawakami A

長崎大学早期関節炎コホートによる2010年ACR/ EULAR RA分類基準の検証

长崎大学早期关节炎队列对 2010 年 ACR/EULAR RA 分类标准的验证

• 发表时间: 2011
• 作者: 玉井慎美;喜多潤子;上谷雅孝;有馬和彦;中島好一;鈴木貴久;岡田覚丈;川尻真也;一瀬邦弘;山崎聡士;中村英樹;折口智樹;青柳潔;江口勝美;川上純
• 通讯作者: 川上純

Treatment discontinuation in patients with very early rheumatoid arthritis in sustained simplified disease activity index remission after synthetic disease-modifying anti-rheumatic drug administration

极早期类风湿性关节炎患者在合成疾病缓解抗风湿药物给药后持续简化疾病活动指数缓解后停止治疗

• 发表时间: 2012
• 期刊: Mod Rheumatol
• 影响因子: 2.2
• 作者: Kita J;Tamai M;Arima K;Nakashima Y;Suzuki T;Kawashiri SY;Iwamoto N;Okada A;Koga T;Yamasaki S;Nakamura H;Origuchi T;Ida H;Aoyagi K;Uetani M;Eguchi K;Kawakami A
• 通讯作者: Kawakami A

Delayed treatment with tumor necrosis factor inhibitors in incomplete responders to synthetic disease-modifying anti-rheumatic drugs shows an excellent effect in patients with very early rheumatoid arthritis with poor prognosis factors

对合成缓解病情抗风湿药物不完全反应的患者延迟使用肿瘤坏死因子抑制剂治疗，对于预后不良的极早期类风湿性关节炎患者显示出良好的效果

• 发表时间: 2012
• 期刊: Mod Rheumatol
• 影响因子: 2.2
• 作者: Kita J;Tamai M;Arima K;Nakashima Y;Suzuki T;Kawashiri SY;Okada A;Koga T;Yamasaki S;Nakamura H;Origuchi T;Aramaki T;Nakashima M;Fujikawa K;Tsukada T;Ida H;Aoyagi K;Uetani M;Eguchi K;Kawakami A
• 通讯作者: Kawakami A