Analysis of the effects of TIM-1 on respiratory epithelial cells on bronchial asthma
Analysis of the effects of TIM-1 on respiratory epithelial cells on bronchial asthma
TIM-1对支气管哮喘呼吸道上皮细胞的影响分析
批准号：
22790973
负责人：
KOBAYASHI Norimoto
金额：
$2.58万
依托单位：
依托单位国家：
日本
项目类别：
Grant-in-Aid for Young Scientists (B)
财政年份：
2010
资助国家：
日本
项目状态：
已结题
起止时间：
2010 至 2012
中文摘要
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英文摘要
To access the function of TIM-1 on respiratory epithelial cells, the human type II alveolar epithelium cell line A549 was used. Although A549 expressed high level of TIM-1 on the cell surface, it was not able to phagocyte apoptotic cells. Moreover, A549 has different TIM-1 mutations among each cell clone. These mutations probably affect the binding between TIM-1 and apoptotic cells.
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