Development of antiviral treatment for paramyxovirus infection that target the L protein
Development of antiviral treatment for paramyxovirus infection that target the L protein
批准号:
22791018
负责人:
SEKI Fumio
金额:
$2.41万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
点击翻译按钮获取中文摘要
英文摘要
P protein with a deletion of amino acids between 307 and 336 (Pd307-336) decreased the interaction between P and P, and P and L protein. Expressing the Pd307-336 inhibited the virus growth. Similar effects were obtained when lacking the N-terminal amino acids of the Pd307-336. I was expressed L protein and mutant P proteins using Escherichia coli as a host.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
The SI Strain of Measles Virus Derived from an SSPE Patient Exhibits Altered Receptor Specificity and Reduced Membrane Fusion Activity
来自 SSPE 患者的麻疹病毒 SI 株表现出受体特异性改变和膜融合活性降低
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Fumio Seki, Yuichiro Nakatsu, Kenji Someya, Maino Tahara, Katsuhiro Komase, Makoto Takeda]
通讯作者:
Makoto Takeda
The SI strain of measles virus derived from a patient with subacute sclerosing panencephalitis possesses typical genome alterations and unique amino acid changes that modulate receptor specificity and reduce membrane fusion activity
源自亚急性硬化性全脑炎患者的麻疹病毒 SI 株具有典型的基因组改变和独特的氨基酸变化,可调节受体特异性并降低膜融合活性
DOI:
10.1128/jvi.05067-11
发表时间:
2011
期刊:
Journal of Virology
影响因子:
5.4
作者:
[Seki F, Yamada K, Nakatsu Y, Okamura K, Yanagi Y, Nakayama T, Komase K, Takeda M]
通讯作者:
Takeda M
イヌジステンパーウイルスの上皮および中枢神経感染におけるイヌNectin4の利用
犬 Nectin4 在犬瘟热病毒上皮和中枢神经系统感染中的应用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Seki F, Yamada K, Nakatsu Y, Okamura K, Yanagi Y, Nakayama T, Komase K, Takeda M, 關 文緒]
通讯作者:
關 文緒
Effects of the cell penetrating peptides-fused protein on inhibition of virus replication
-
批准号:26860835
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.08万
-
财政年份:2014
-
负责人:SEKI Fumio
-
依托单位:
海外基金