Development of a circuit with a high-performance membranous oxygenator for using an artificial placenta in a premature lamb model

由于以前的研究，旨在开发人工胎盘的成功有限，我们假设，引入一个高性能的膜式氧合器的无泵人工胎盘可以延长早产羔羊的生存时间。胎儿娩出后，立即将脐血管插管并连接至无泵人工胎盘。胎仔和回路均浸没在温盐水浴中。5例胎儿存活18年。2 ± 3。贴附人工胎盘后2（平均值± SEM）小时，人工胎盘维持胎儿循环。我们使用高性能的膜式氧合器以小的预充体积延长胎羊的存活。

Because previous studies aimed at developing an artificial placenta have had limited success, we hypothesized that the introduction of a high-performance membranous oxygenator to a pumpless artificial placenta could prolong the survival time of premature lambs. Immediately after the delivery of the fetuses, the umbilical vessels were cannulated and connected to the pumpless artificial placenta. Both the fetuses and the circuit were submerged in a warm saline bath. Five fetuses survived for 18. 2 ± 3. 2 (mean ± SEM)hours after attachment to the artificial placenta, which maintained the fetal circulation. We prolonged the survival of fetal lambs using a high-performance membranous oxygenator with a small priming volume.