Development of a circuit with a high-performance membranous oxygenator for using an artificial placenta in a premature lamb model

由于之前旨在开发人造胎盘的研究取得的成功有限，我们假设在无泵人造胎盘中引入高性能膜氧合器可以延长早产羔羊的存活时间。胎儿出生后，立即插入脐带血管并连接到无泵的人造胎盘上。胎儿和电路都浸入了温暖的盐水浴中。5例胎儿附着人工胎盘后存活18.2±3.2小时，维持胎儿血液循环。我们使用高性能的膜式氧合器和较小的预充量延长了胎羊的存活。

Because previous studies aimed at developing an artificial placenta have had limited success, we hypothesized that the introduction of a high-performance membranous oxygenator to a pumpless artificial placenta could prolong the survival time of premature lambs. Immediately after the delivery of the fetuses, the umbilical vessels were cannulated and connected to the pumpless artificial placenta. Both the fetuses and the circuit were submerged in a warm saline bath. Five fetuses survived for 18. 2 ± 3. 2 (mean ± SEM)hours after attachment to the artificial placenta, which maintained the fetal circulation. We prolonged the survival of fetal lambs using a high-performance membranous oxygenator with a small priming volume.