Analysis of magnetic resonance imaging in cerebral white matter injury using chronically instrumented fetal sheep

我们分析了长期仪器化的胎羊在子宫内缺血和/或炎症的脑白质损伤（WMI）的磁共振成像（MRI）。5例局灶性WMI胎儿MRI信号异常，3例非局灶性WMI胎儿MRI信号异常，表现为局灶低T1、弥漫性高T2或局灶高T1 /低T2强度。后一组观察到的这些异常信号可能反映了弥漫性WMI急性期的组织学改变，在临床上比局灶性WMI更重要。因此，下一步有必要通过添加免疫组织化学分析来评估白质中少突胶质细胞的发育。

We analyzed the magnetic resonance imaging (MRI) in the cerebral white matter injury (WMI) using chronically instrumented fetal sheep, suffered from ischemia and/or inflammation in utero. Abnormal MRI signals were found in 5 fetuses induced focal WMI while unexpectedly also found in 3 fetuses not induced WMI, as a focal low T1, diffuse high T2 or focal high T1 /low T2 intensity. It might be possible that these abnormal signals observed in the latter group reflected histologic changes in acute phase of diffuse WMI, clinically more important than focal WMI. Consequently, it would be necessary to be evaluated the oligodendroglial development in the white matter by adding the immuno-histochemical analysis as a next step.