Influence of fetal growth restriction on gastrointestinal function in preterm infants

胎儿生长受限对早产儿胃肠功能的影响

• 批准号: 22791039
• 负责人: SHOJI Hiromichi
• 金额: $ 1.91万
• 依托单位: Juntendo University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791039/
• 关键词: 未熟児医学; 新生児医学; 小児栄養学; 上部消化管学; 早産児; 低出生体重児; インスリン抵抗性; HOMA-IR; 子宮内発育不全; 脂質代謝

To determine the influence of fetal growth restriction on markers of metabolic syndrome(MS), we assessed lipid and apolipoprotein metabolism at discharge in preterm infants. Blood samples were collected at discharge from preterm infants divided into a group whose birth weight was small for their gestational age(SGA group) and a group whose birth weight was appropriate for their gestational age(AGA group). Serum T-cho, HDL, LDL, apo AI and apo B levels were measured, and the ratios of T-cho/HDL, LDL/HDL and apo B/apo AI were calculated. T-cho/HDL, LDL/HDL and apo B/apo AI ratios were significantly higher in the SGA group than in the AGA group. Our data suggest that poor fetal growth may affects lipid metabolism(the markers of MS) in preterm infants.

为了确定胎儿生长受限对代谢综合征（MS）标志物的影响，我们评估了早产儿出院时的脂质和载脂蛋白代谢。在早产儿出院时采集血样，分为出生体重小于胎龄组（SGA组）和出生体重适合胎龄组（阿加组）。测定血清T-cho、HDL、LDL、apo AI和apo B水平，计算T-cho/HDL、LDL/HDL和apo B/apo AI比值。SGA组T-cho/HDL、LDL/HDL和apo B/apo AI比值均显著高于阿加组。我们的数据表明，胎儿生长不良可能会影响早产儿的脂质代谢（MS的标志物）。

项目成果

Influence of fetal growth restriction on glucose metabolism at birth in very premature infants

胎儿生长受限对极早产儿出生时糖代谢的影响

• 发表时间: 2011
• 作者: Shoji H;et al.
• 通讯作者: et al.

NICU退院時における早産児の脂質代謝に関する検討

NICU出院早产儿脂质代谢研究

• 发表时间: 2011
• 作者: Shoji H;et al.;東海林宏道ら
• 通讯作者: 東海林宏道ら