Angiogenesis, neurogenesis and anti-depressive effect of CD34 positive stem cell transplantation in rat brain.

在最近的研究中，脑血流量的恢复成为治疗抑郁症的一种新策略。为了建立治疗方法研究的动物模型，本课题尝试通过颈内动脉将CD34阳性的造血干细胞移植到大鼠脑内，并成功地证实了其在输注后大鼠脑内毛细血管内的增殖。然而，我很遗憾地停止了这个项目，因为在输血后1周内，大鼠的存活率不到60%。

In recent studies, recovery of cerebral blood flow emerged as a novel therapeutic strategy for depression. To establish animal model for the therapy method research, I tried to transplant CD34 positive hematopoietic stem cell into rat brain through the internal carotid artery and succeeded to confirm its proliferation in the rat brain capillaries after transfusion in this project. However, I regretted to discontinue the project because the survival rate of rat was less than 60% within 1 week after transfusion.