Angiogenesis, neurogenesis and anti-depressive effect of CD34 positive stem cell transplantation in rat brain.

CD34阳性干细胞移植大鼠脑血管生成、神经发生和抗抑郁作用。

• 批准号: 22791119
• 负责人: KAMENO Yosuke
• 金额: $ 2.58万
• 依托单位: Hamamatsu University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791119/
• 关键词: 精神生理学; 血管・神経新生; うつ病; 脳内血流; CD34

In recent studies, recovery of cerebral blood flow emerged as a novel therapeutic strategy for depression. To establish animal model for the therapy method research, I tried to transplant CD34 positive hematopoietic stem cell into rat brain through the internal carotid artery and succeeded to confirm its proliferation in the rat brain capillaries after transfusion in this project. However, I regretted to discontinue the project because the survival rate of rat was less than 60% within 1 week after transfusion.

在最近的研究中，恢复脑血流量成为抑郁症的一种新的治疗策略。为了建立治疗方法研究的动物模型，本项目尝试将CD34阳性造血干细胞经颈内动脉移植到大鼠脑内，并成功证实其输血后在大鼠脑毛细血管中增殖。然而，我很遗憾地终止了这个项目，因为输血后1周内大鼠的存活率还不到60%。