Study on disability of the acoustic sense memory in adult with slightly developmental disorder

对54例成人AD/HD患者、43例精神分裂症患者(SZ)和40例健康志愿者(HC)的事件相关电位(ERP)ND、N2b和P300进行比较。众所周知，ND、N2b和P300分别反映了选择性注意、自愿注意和认知语境更新。成人AD/HD组和SZ组P300波幅明显低于HC组。晚期ND、N2b、P300波峰潜伏期SZ组明显长于HC组和成人AD/HD组。因此，SZ组各种事件相关电位成分的波幅衰减和潜伏期延长提示认知加工的基本机制可能受损。与SZ组不同，成年AD/HD组P300波幅降低，潜伏期未见延长。这些发现表明，成人AD/HD组存在一种不同类型的认知功能障碍，这可能与注意功能密切相关。

Event-related potentials (ERPs) such as Nd, N2b, and P300 were compared among 54 adult AD/HD patients, 43 schizophrenic patients (SZ), and 40 healthy age-matched volunteers (HC). It is known that Nd, N2b, and P300 reflect selective attention, voluntary attention, and cognitive context updating respectively. The peak amplitude of P300 was significantly lower in the adult AD/HD and SZ groups than in the HC group. The peak latencies of late Nd, N2b, and P300 were significantly longer in the SZ group than in the HC and adult AD/HD groups. Thus, attenuated amplitude and prolonged latency of various ERP components in the SZ group suggest the possibility of impairment of basic mechanisms underlying cognitive processing. Unlike the SZ group, the adult AD/HD group exhibited reduced amplitude of P300 but not prolonged latency. These findings suggest the existence of a different type of cognitive dysfunction in the adult AD/HD group, which might be closely related to attentional function.