Search for biomarkers of bipolar disorder

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To search for biomarker of bipolar disorder, we extracted proteins derived from lymphoblastoid cells of monozygotic twins discordant for bipolar disorder and compared protein levels between patients with bipolar disorder and co-twin using two-dimensional fluorescence difference gel electrophoresis. Using antibodies against a part of proteins identified, we performed the case-control study by using western blot analysis. We identified a glycolysis related protein that is different expression levels between patients and healthy controls. The protein may be a biomarker of bipolar disorder.