Research for efficacy of radiation-induced auto-immune response in radiation therapy

放射治疗中放射诱发的自身免疫反应的疗效研究

• 批准号: 22791169
• 负责人: ISHIKAWA Hitoshi
• 金额: $ 2.5万
• 依托单位: University of Tsukuba (2011)Gunma University (2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791169/
• 关键词: 腫瘍免疫; 放射線治療; サイトカイン; 抗腫瘍免疫; 抗体療法

TCD50 of the tumors was estimated to be 40 Gy, and all cytokine levels in the plasma were up-regulated with radiation-dose-dependency. After TCD50 irradiation to the 10 tested tumors, 5 were controlled (C-group) and 5 developed progression within 14 days (R-group). The levels of GM-CSF, IFN-γ, and TNF-α in the supernatants of 48 hr-cultivated spleen cells obtained 28 days after irradiation in the C-group (48 hr) were 37.8 ± 10.1 pg/ml, 5.4 ± 6.9 pg/ml, and 21.2 ± 6.6 pg/ml, respectively, but those in the R-group were 23.7 ± 13.0 pg/ml, 0.6 ± 0.6 pg/ml, and 13.1 ± 5.6 pg/ml, respectively. A significant difference in IFN-γ between the two groups was observed. Similarly, plasma IFN-γ level 28 days after 40 Gy-irradiation in the C-group (12.0 ± 18.7 pg/ml) was higher than that in the R-group (0.9 ± 0.7 pg/ml), but the difference did not reach the significant level.

肿瘤的TCD 50估计为40戈伊，并且血浆中的所有细胞因子水平均上调，具有辐射剂量依赖性。10个受试肿瘤经TCD 50照射后，5个肿瘤控制（C组），5个肿瘤在14天内进展（R组）。照射后28天（48小时），C组脾细胞培养48小时上清液中GM-CSF、IFN-γ和TNF-α的含量分别为37.8 ± 10.1 pg/ml、5.4 ± 6.9 pg/ml和21.2 ± 6.6 pg/ml，而R组分别为23.7 ± 13.0 pg/ml、0.6 ± 0.6 pg/ml和21.2 ± 6.6 pg/ml。13.1 ± 5.6pg/ml。IFN-γ在两组之间观察到显著差异。40 Gy照射后28 d，C组血浆IFN-γ水平（12.0 ± 18.7pg/ml）高于R组（0.9 ± 0.7pg/ml），但差异不显著。

项目成果

Comparison of Chemoradiotherapy with Radiotherapy Alone in Patients with Esophageal Adenocarcinoma

• DOI: 10.1269/jrr.10166
• 发表时间: 2011-05-01
• 期刊: JOURNAL OF RADIATION RESEARCH
• 影响因子: 2
• 作者: Shirai, Katsuyuki;Tamaki, Yoshio;Nakano, Takashi
• 通讯作者: Nakano, Takashi

前立腺癌に対する炭素イオン線治療の初期経験

碳离子治疗前列腺癌的早期经验

• 发表时间: 2010
• 作者: 石川仁;加藤弘之;大野達也ら
• 通讯作者: 大野達也ら

I期食道癌に対する高線量率腔内照射と低線量率腔内照射の治療成績比較

Ⅰ期食管癌高剂量率腔内照射与低剂量率腔内照射治疗效果比较

• 发表时间: 2010
• 作者: 石川仁;高橋健夫;玉木義雄ら
• 通讯作者: 玉木義雄ら

放射線治療効果予測に関する基礎的研究

预测放射治疗效果的基础研究

• 发表时间: 2010
• 作者: Ishikawa H;Katoh H;Ebara T;et al;石川仁
• 通讯作者: 石川仁

中・高リスク前立腺癌に対する高線量率組織内照射の治療成績

高剂量率间质照射治疗中高危前列腺癌的效果

• 发表时间: 2010
• 作者: 石川仁;加藤弘之;江原威ら
• 通讯作者: 江原威ら