Development of contrast-enhanced MR lymphangiography usingclinically available medical agents

使用临床可用的药物开发对比增强磁共振淋巴管造影术

• 批准号: 22791181
• 负责人: KOSAKA Nobuyuki
• 金额: $ 2.58万
• 依托单位: University of Fukui
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791181/
• 关键词: 放射線; MRI; リンパ管; リンパ節; トランスレーショナル

The purpose of this study was to develop novel contrast-enhanced MR lymphangiography methods using clinically available medical agents. First, we employed optical imaging methods to reveal that subcutaneous injection of fluid depicted lymphatic basins in mice, and then MR imaging was conducted with healthy volunteers. After subcutaneous injection of saline (clinically available medical agents) at forearm, lymphatic ducts were clearly depicted on heavy T2 weighted images with post-image processing.

本研究的目的是利用临床可用的药物开发新的对比增强MR淋巴管造影方法。首先，我们采用光学成像方法揭示皮下注射液体描绘的小鼠淋巴盆地，然后对健康志愿者进行磁共振成像。在前臂皮下注射生理盐水（临床可用的药物）后，经过图像后处理的重T2加权图像清晰地描绘了淋巴管。

项目成果

Clinical Applications of Contrast-Enhanced Optical Imaging in Cancer

对比增强光学成像在癌症中的临床应用

• 发表时间: 2012
• 作者: A. Sakumi;K. Shiraishi;T. Onoe;K. Yamamoto;A. Haga;et al.;小坂信之 他
• 通讯作者: 小坂信之 他