The challenge to the liver transplantation by a fatty liver.- Treatment strategy for inflammation and coagulation by ischemia reperfusion injury.

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1)In the rat liver ischemia reperfusion model , the hepatic protection effect of recombination human soluble thrombomodulin (rhsTM) was examined.In the rhsTM group, liver enzymeserum, ED-1, TUNEL , and PCNA immunostaining reveal effect of rhsTM administration.2)We examined coagulation and anti-anticoagulation factor in living donor liver transplantation patient. The blood platelet low value (100,000 or less) of continuation was a prognostic factor after liver transplantation. To determine risk factors associated with prolonged thrombocytopenia following LDLT, with a focus on the activity of ADAMTS13 (a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs member 13) and the influence of splenectomy.Prolonged thrombocytopenia after LDLT was associated with not only a decrease in ADAMTS13 due to sinusoidal endothelial cell injury, but also low TPO production due to hepatocyte dysfunction, irrespective of history of splenectomy.