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Role of the FOXF2 gene in the cancer activated fibroblasts that support proliferation of colon cancer cells

Role of the FOXF2 gene in the cancer activated fibroblasts that support proliferation of colon cancer cells
FOXF2 基因在支持结肠癌细胞增殖的癌症激活成纤维细胞中的作用
批准号:
22791272
负责人:
SULTANA Nishat
金额:
$2.58万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
When colon cancer cells HT29 were transplanted with intestinal embryonic fibroblasts(IEFs) from the Foxf2-/-and wild-type mice, the efficiency and tumor size were highest in cotranslantation with the wild-type IEFs, higher in that with the Foxf2-/-IEFs compared to that without fibroblasts. I isolated RNas from IEFs from the Foxf2-/-and wild-type mice and applied to DNA microarray analysis. I found 23 genes were significantly higher in the wild-type compared to the Foxf2-/-mice. I chose one gene named Wnt5a and demonstrated that the Wnt5a-expressing fibroblasts increased the efficiency and tumor size of HT29 cell transplantation.
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Liver tumor formation by a mutant retinoblastoma protein in the transgenic mice is caused by an up-regulation of c-Myc target genes
转基因小鼠中突变视网膜母细胞瘤蛋白形成的肝脏肿瘤是由 c-Myc 靶基因上调引起的
DOI: --
发表时间: 2012
期刊: Biochem Biophys Res Commun
影响因子: --
作者: [Wang B, Hikosaka K, Sultana N, Sharkar MTK, Noritake H, Kimura W, Wu Y-X, Kobayashi Y, Uezato T, Miura N]
通讯作者: Miura N
Irxl1 mutant mice show reduced tendon differentiation and no pattening defects in musculoskletal system development.
Irxl1 突变小鼠表现出肌腱分化减少,并且在肌肉骨骼系统发育中没有模式缺陷。
DOI: --
发表时间: 2011
期刊: Genesis
影响因子: 1.5
作者: [Kimura, W., et al.]
通讯作者: et al.
Irx3 determines expression of fast and slow connexins in the ventricular conduction system of the mouse heart
Irx3 决定小鼠心脏心室传导系统中快速和慢速连接蛋白的表达
DOI: --
发表时间: 2011
期刊:
影响因子: --
作者: [Sultana N, 他]
通讯作者:
DOI: 10.1016/j.lfs.2010.05.009
发表时间: 2010-07
期刊: Life sciences
影响因子: 6.1
作者: [Zhi Yang;Keisuke Hikosaka;M. Sharkar;T. Tamakoshi;Abhishek Chandra;Bo Wang-;Tatsuo Itakura;Xiaodong Xue;T. Uezato;Wataru Kimura;N. Miura]
通讯作者: Zhi Yang;Keisuke Hikosaka;M. Sharkar;T. Tamakoshi;Abhishek Chandra;Bo Wang-;Tatsuo Itakura;Xiaodong Xue;T. Uezato;Wataru Kimura;N. Miura
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