Over-expression of the RD RNA binding protein is associated with portal vein invasion in hepatocellular carcinoma.

肝细胞癌组织中RDBP的mRNA和蛋白水平均显著高于非肝细胞癌组织，有PVI的肝细胞癌组织中RDBP的表达水平也显著高于无PVI的肝细胞癌组织。多变量分析显示，RDBP蛋白水平是肝癌术后两年内早期肝内复发的独立危险因素。RDBP蛋白的敲除显著抑制了细胞的体外增殖和侵袭。这些数据表明RDBP与肝细胞癌的转移潜能有关，提示RDBP可能是预防肝细胞癌转移的候选基因。

Both mRNA and protein levels of RDBP were significantly higher in HCC than in non-HCC liver tissue, and that these levels were also significantly higher in HCC with PVI than in HCC without PVI. Multivariate analysis revealed that RDBP protein levels were an independent risk factor for early intrahepatic recurrence of HCC within two years of surgery. Knockdown of RDBP protein significantly inhibited the proliferation and invasion of cells invitro. These data demonstrate that RDBP is related to the metastatic potential of HCC, suggesting a possible candidate for prevention of HCC cell metastasis.