Over-expression of the RD RNA binding protein is associated with portal vein invasion in hepatocellular carcinoma.

RDBP的mRNA和蛋白水平在HCC中显著高于非HCC肝组织，并且这些水平在伴有PVI的HCC中也显著高于不伴有PVI的HCC。多因素分析显示RDBP蛋白水平是HCC术后2年内早期肝内复发的独立危险因素。敲低RDBP蛋白可显著抑制细胞的增殖和侵袭能力。这些数据表明RDBP与HCC的转移潜能相关，提示其可能是预防HCC细胞转移的候选物。

Both mRNA and protein levels of RDBP were significantly higher in HCC than in non-HCC liver tissue, and that these levels were also significantly higher in HCC with PVI than in HCC without PVI. Multivariate analysis revealed that RDBP protein levels were an independent risk factor for early intrahepatic recurrence of HCC within two years of surgery. Knockdown of RDBP protein significantly inhibited the proliferation and invasion of cells invitro. These data demonstrate that RDBP is related to the metastatic potential of HCC, suggesting a possible candidate for prevention of HCC cell metastasis.