The role of erbB2 during bile-promotedesophageal carcinogenesis

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To determine whether interaction between erbB2 and bile acids is important in the etiology of esophageal cancers using BK5.erbB2 mice. In both BK5.erbB2 and wild type mice, mice were treated with porcine bile extract, taurochenodeoxycholate or water control, 3 times weekly for 14W by gavage. The bile treatment increased the levels of p-EGFR, and p-MAPK, in the forestomachs of the BK5.erbB2 mice. Furthermore, CDX2 (a marker of Barrett’s Esophagus) was significantly expressed in BK5.erbB2 mice treated with bile. These results indicate that the interaction between erbB2 and bile acids is important in esophageal tumor formation and intestinal metaplasia.