Relationship between transcriptional factor HOXB9 and evasive resistance in colorectal cancer

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Transcriptional factor HOXB9 induced human colon cancer cell lines expressed activation of TGFβpathway and secretion of angiogenic factors including VEGF. In xenograft model of nude mice, HOXB9 overexpressed xenografts showed much rapider growth than control. Moreover, HOXB9 overexpressed xenografts had significantly higher tumor shrinkage rate than control in the treatment of bevacizumab. Thus, transcriptional factor HOXB9 may be a candidate for a biomarker of the treatment of bevacizumab in colorectal cancer patients.