Real-time monitoring of autophagy induced by treatment in malignant glioma

研究表明，包括替莫唑胺在内的多种化疗药物均可诱导自噬，替莫唑胺是恶性胶质瘤的标准治疗药物。此外，药物治疗后自噬的系列诱导尚不清楚，将通过延时成像来阐明。获得自噬抑制剂联合治疗的数据。在验证体外治疗的有效组合和时机时，这些数据可以成为非常重要的信息。

It has been shown that autophagy is induced by various chemotherapeutic drugs including Temozolomide, which is the standard treatment for malignant gliomas. Moreover, the serial induction of autophagy after the medical treatment, which was not clear, will be elucidated by employing time-lapse imaging. Data of combination treatment with autophagy inhibitors were obtained. These data can become very important information when verifying effective combinations and timing of treatments in vitro.