Elucidation of the mechanism of the spinal cord injury by q-space imaging

q空间成像阐明脊髓损伤机制

• 批准号: 22791401
• 负责人: FUJIYOSHI Kanehiro
• 金额: $ 2.58万
• 依托单位: Clinical research Center, National Hospital Organization Murayama Medical Center (2011)Keio University (2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791401/
• 关键词: 脊髄損傷; MRI; コモンマーモセット; 髄鞘; 脱髄; 再髄鞘化; 神経幹細胞移植; q-spaceイメージング; 神経管細胞移植

Here we developed the "Myelin map," an enhanced myelin visualization method based on q-space MR imaging. This method visualizes the highly restricted diffusion of water molecules in myelin sheaths. Myelin maps accurately depicted the poor myelination in myelin-deficient mice, the demyelination/remyelination in marmoset chemical SCI, and the remyelination after allogeneic NS/PC transplantation in marmosets. Myelin maps have an unparalleled ability to visualize demyelination/remyelination and the potential for immediate clinical application as a powerful tool for researchers and clinicians examining diseases of the central nervous system(CNS).

在这里，我们开发了“髓磷脂图”，这是一种基于 q 空间 MR 成像的增强髓磷脂可视化方法。该方法可视化水分子在髓鞘中高度受限的扩散。髓磷脂图准确地描绘了髓磷脂缺陷小鼠的髓鞘形成不良、狨猴化学 SCI 中的脱髓鞘/髓鞘再生以及狨猴同种异体 NS/PC 移植后的髓鞘再生。髓磷脂图具有无与伦比的脱髓鞘/髓鞘再生可视化能力，并且具有立即临床应用的潜力，可以作为研究人员和临床医生检查中枢神经系统 (CNS) 疾病的强大工具。

项目成果

q-space MR imaging depict demyelination after spinal cord injury in non-human primate

q 空间 MR 成像描绘非人类灵长类动物脊髓损伤后的脱髓鞘

• 发表时间: 2011
• 作者: K Fujiyoshi;O Tsuji;T Konomi;K Hikishima;M Yamada;S Momoshima;H Okanno;Y Toyama;M Nakamura
• 通讯作者: M Nakamura

A novel in vivo myelin MR imaging elucidated the mechanism of spinal cord injury

一种新型的体内髓磷脂磁共振成像阐明了脊髓损伤的机制

• 发表时间: 2011
• 作者: K Fujiyoshi;T Konomi;O Tsuji;K Hikishima;S Momoshima;M Matsumoto;K Chiba;H Okanno;Y Toyama;M Nakamura
• 通讯作者: M Nakamura

Long-Term Surgical Outcomes of Spinal Meningiomas

• DOI: 10.1097/brs.0b013e31824167f1
• 发表时间: 2012-05-01
• 期刊: SPINE
• 影响因子: 3
• 作者: Nakamura, Masaya;Tsuji, Osahiko;Matsumoto, Morio
• 通讯作者: Matsumoto, Morio

Human hepatocyte growth factor promotes functional recovery in primates after spinal cord injury.

• DOI: 10.1371/journal.pone.0027706
• 发表时间: 2011
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kitamura K;Fujiyoshi K;Yamane J;Toyota F;Hikishima K;Nomura T;Funakoshi H;Nakamura T;Aoki M;Toyama Y;Okano H;Nakamura M
• 通讯作者: Nakamura M

脊髄損傷モデルおよび再生過程における軸索および髄鞘の可視化の試み

尝试可视化脊髓损伤模型和再生过程中的轴突和髓鞘

• 发表时间: 2011
• 作者: Hiyama A;Sakai D;Arai F;Nakajima D;Yokoyama K;Mochida J;Suehara Y et al;藤吉兼浩
• 通讯作者: 藤吉兼浩