Elucidation of the mechanism of the spinal cord injury by q-space imaging

在这里，我们开发了“髓鞘图谱”，这是一种基于Q-空间磁共振成像的增强的髓鞘可视化方法。这种方法显示了水分子在髓鞘中高度受限的扩散。髓鞘图谱准确地描绘了髓鞘缺陷小鼠的髓鞘缺失、绒猴化学脊髓损伤后的脱髓鞘/再髓鞘以及同种异体NS/PC移植后的再髓鞘形成。髓鞘图谱具有无与伦比的显示脱髓鞘/重新髓鞘形成的能力，并有可能立即应用于临床，作为研究人员和临床医生检查中枢神经系统(CNS)疾病的强大工具。

Here we developed the "Myelin map," an enhanced myelin visualization method based on q-space MR imaging. This method visualizes the highly restricted diffusion of water molecules in myelin sheaths. Myelin maps accurately depicted the poor myelination in myelin-deficient mice, the demyelination/remyelination in marmoset chemical SCI, and the remyelination after allogeneic NS/PC transplantation in marmosets. Myelin maps have an unparalleled ability to visualize demyelination/remyelination and the potential for immediate clinical application as a powerful tool for researchers and clinicians examining diseases of the central nervous system(CNS).