Cellular and molecular biological analysis of the impact of drugs used during periorerative period on cellular oxygen metabolism

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We demonstrated that Glucose-stimulated insulin secretion(GSIS) elicited by 400 mg/dL glucose was inhibited by treatment with isoflurane and sevoflurane. Taken together experimental evidence that glibenclamide-stimulated insulin secretion was not affected by either isoflurane or sevoflurane and that treatment with isoflurane or sevoflurane significantly suppress glucose-induced intracellular ATP elevation, it is suggested that isoflurane and sevoflurane affect mitochondria ETC and suppresses GSIS. Our finding may delineate the molecular mechanism behind the glucose tolerance established by volatile anesthetics.