The possibility of perioperative organ protection by inducing Hsp70

我们研究了术前给予抗溃疡药物替普诺通过诱导HSP70对围手术期器官的保护作用。健康志愿者服用替普瑞酮（150 mg/d p. o.），研究其在外周血中的诱导作用，但未检测到HSP70。8名计划进行腰椎手术的患者被分配接受替普利诺或不接受药物治疗（对照组）。测定血液学指标、急性期蛋白、细胞因子、肝功能、肾功能。给药组术后IL-6水平有低于对照组的趋势。提示泰普孕酮可能具有围手术期器官保护作用。需要进一步的研究来确定HSP70在更多患者中的诱导作用。

We investigated the effect of preoperative administration of teprenone, an anti ulcer drug, for perioperative organ protection by inducing HSP70. Teprenone(150 mg/day p. o.) was administered to healthy volunteers and we studied the induction in peripheral blood for 4 days, however, HSP70 was undetectable. Eight patients scheduled for lumbar spinal spine surgery were assigned to receive either teprenone or no medication(control). Hematological parameters, acute phase proteins, cytokines, liver function and renal function were determined. The postoperative IL-6 level tended to be lower in the administered group than that of the control group. This suggests the possible perioperative organ protection of teprenone. Further research is needed to determine the induction of HSP70 in more patients.