The possibility of perioperative organ protection by inducing Hsp70

诱导 Hsp70 围手术期器官保护的可能性

• 批准号: 22791447
• 负责人: NAKANO Yuko
• 金额: $ 1.25万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791447/
• 关键词: Hsp70; テプレノン; サイトカイン

We investigated the effect of preoperative administration of teprenone, an anti ulcer drug, for perioperative organ protection by inducing HSP70. Teprenone(150 mg/day p. o.) was administered to healthy volunteers and we studied the induction in peripheral blood for 4 days, however, HSP70 was undetectable. Eight patients scheduled for lumbar spinal spine surgery were assigned to receive either teprenone or no medication(control). Hematological parameters, acute phase proteins, cytokines, liver function and renal function were determined. The postoperative IL-6 level tended to be lower in the administered group than that of the control group. This suggests the possible perioperative organ protection of teprenone. Further research is needed to determine the induction of HSP70 in more patients.

我们研究了术前给予抗溃疡药物替普瑞酮通过诱导HSP 70对围手术期器官保护的作用。替普瑞酮（150 mg/天p.o.）给健康志愿者注射，我们研究了外周血中的诱导作用4天，然而，检测不到HSP 70。8例计划进行腰椎手术的患者被分配接受替普瑞酮或不接受药物治疗（对照组）。检测血液学指标、急性时相蛋白、细胞因子、肝功能和肾功能。术后IL-6水平在给药组中有低于对照组的趋势。这表明替普瑞酮可能具有围手术期器官保护作用。需要进一步的研究来确定更多患者中HSP 70的诱导。