Evaluation of completeness using different diameters and types of suture materials for chronic constriction injury model in rat

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We evaluated the completeness of Bennett method using different diameters and types of suture materials. In this study, (1) digit transformation of injured leg and the pain-related behavior, (2)automatic behavior analysis (the number of rearing, length of rearing and total walking distance) and (3) histologic findings of sciatic nerve were examined.Results: four weeks after constriction of sciatic nerve, digit transformation and the pain-related behavior was showed with 4 of 5 in 1-0 silk thread group, 1 of 5 in 4-0 silk thread group, 4 of 7 in 4-0 nylon sutures group. Histological changes appeared in sciatic nerve was frequent in order of 1-0 silk thread> 4-0 nylon suture> 4-0 silk thread.Discussion: We found that the 1-0 silk is the best suture material for chronic constriction injury model (Bennett model) in rat.