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The study of the new molecular cancer treatment targeting for apoptosis inhibitor survivin.

The study of the new molecular cancer treatment targeting for apoptosis inhibitor survivin.
以凋亡抑制剂survivin为靶点的新型分子癌症治疗研究。
批准号:
22791466
负责人:
KOIKE Hidekazu
金额:
$1.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011

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中文摘要
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英文摘要
We suggested that survivin have significant associations with prostate cancer cell proliferation, plays an essential role in simvastatin induced cell growth inhibition, and plays an essential role in active D3 induced cell growth inhibition in prostate cancer. The elimination of Survivin would be also a potential candidate for a novel approach to treat prostate cancer.In renal cell cancer, simvastatin has anticancer effect being associated with IGF-1r. Survivin is associated with simvastatin resistance of renal cancer cells.
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会议论文
Statin inhibits the proliferation of human prostate cancer cells via down-regulation of the survivin
他汀类药物通过下调生存素抑制人前列腺癌细胞的增殖
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Hidekazu Koike, et al.]
通讯作者: et al.
スタチンのsurvivin抑制による腎癌細胞増殖抑制効果
他汀类药物survivin抑制肾癌细胞增殖的作用
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Hidekazu Koike, et al., 小池秀和, 小池秀和, 小池秀和, 小池秀和]
通讯作者: 小池秀和
Survivin is associated with cell proliferation and has a role in la,25-dihydroxyvitamin D3 induced cell growth inhibition in prostate cancer
生存素与细胞增殖相关,并在 1a,25-二羟基维生素 D3 诱导的前列腺癌细胞生长抑制中发挥作用
DOI: --
发表时间: 2011
期刊: Journal of Urology
影响因子: 6.6
作者: [Hidekazu Koike, et al., Hidekazu Koike]
通讯作者: Hidekazu Koike
Statin inhibits the proliferation of human prostate cancer cells via down-regulation of the survivin.
他汀类药物通过下调生存素来抑制人前列腺癌细胞的增殖。
DOI: --
发表时间: 2010
期刊:
影响因子: --
作者: [Hidekazu Koike, et al., 小池秀和]
通讯作者: 小池秀和
12
    Basic study of the treatment with anti-survivin and heavy ion radiotherapy for drug-resistant kidney and prostate cancer.
    • 批准号:
      25462467
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.25万
    • 财政年份:
      2013
    • 负责人:
      KOIKE Hidekazu
    • 依托单位:
    A study of the molecule target treatment about survivin, an apoptosis inhibitor, in the prostate and renal cancer.
    • 批准号:
      20791101
    • 项目类别:
      Grant-in-Aid for Young Scientists (B)
    • 资助金额:
      $1.91万
    • 财政年份:
      2008
    • 负责人:
      KOIKE Hidekazu
    • 依托单位:
    海外基金