The mechanism of urolithiasis formation and the analysis of adipocytokine under metabolic syndrome

在本研究中，Mets环境中肾脏晶体的形成增加了OPN和MCP-1的表达，并降低了肾脏组织中SOD的表达。总体而言，APN可能通过在生物分子水平上调节炎症和氧化应激来预防肾结石。接下来，肾小管上皮细胞和脂肪细胞在共培养中表现出肾结石相关基因的特征性表达模式。这些现象可能与蛋氨酸环境诱导肾小管上皮细胞与脂肪细胞之间的旁分泌系统有关，提示蛋氨酸环境可能导致肾结石的形成。

In this study, Kidney crystal formation in the MetS environment increased OPN and MCP-1 expression, and decreased SOD expression in renal tissue. Collectively, APN is possible to prevent kidney stone by regulating inflammation and oxidative stress at the biomolecular level. Next, the renal tubular epithelial cells and adipocytes showed characteristic expression patterns of kidney stone-related genes in the coculture. These phenomena might be due to MetS environment-induced paracrine system between renal tubular epithelial cells and adipocytes, and suggests that MetS environment may lead to kidney stone formation.