Oxygen nano-bubble water reduces renal calcium oxalate deposits and renal tubular cell injury in a hyperoxaluric rat model

肾结石在发生机制、钙化成分和流行病学上与动脉硬化相似。含有氧纳米气泡（由氧微气泡产生的纳米尺寸气泡; ONB水）的水具有抗炎作用。基于这些抗炎作用，ONB水已被报道为动脉粥样硬化的有用疗法。因此，我们使用高尿酸大鼠模型研究ONB水对肾结石形成的抑制作用。我们的研究结果表明，ONB水减少高尿酸大鼠的晶体保留，由于减少肾小管细胞损伤和晶体结合分子（骨桥蛋白：OPN和透明质酸：HA）的表达。

Kidney stone resembles arteriosclerosis in the mechanism, calcification composition and epidemiology. Water including oxygen nano-bubbles(nanometer-sized bubbles generated from oxygen microbubbles ; ONB water) has anti-inflammatory effects. Based on these anti-inflammatory effects, ONB water has been reported as a useful therapy for atherosclerosis. Therefore, we investigated the inhibitory effects of ONB water on kidney stone formation using a hyperoxaluric rat model. Our results suggest that ONB water reduces crystal retention in hyperoxaluric rats due to decreased renal tubular cell injury and resulting expression of crystal binding molecules(osteopontin : OPN and hyaluronic acid : HA).