Analysis of ALDH1 activity in stem cells of endometrium and endometrial cancer

来源于正常人子宫内膜的原代培养细胞含有ALDH 1高群体。HER 2在ALDH-高表达细胞与对照组间无差异。低细胞与非干细胞相比，子宫内膜癌干细胞中ALDH 1活性增强。将dbpC导入子宫内膜癌细胞可增强干细胞亚群以及ALDH 1表达水平。这些结果表明，ALDH 1是子宫内膜癌干细胞的候选标记物。

Primary cultured cells derived from normal human endometrium contained ALDH1-high population. There was no difference of expression of HER2 between ALDH-high cells and. low cells. ALDH1 activity was enhanced in endometrial cancer stem cells compared with that in non-stem cells. Introduction of dbpC to endometrial cancer cells enhanced subpopulations of stem cells as well as the level of ALDH1 ecpression. These results demonstrated that ALDH1 was a candidate for marker of endometrial cancer stem cells.