Immunomodulation and neuroprotection in experimental uveoretinitis by regulation of HMGB-1

我们研究了高迁移率组框（High Mobility Group Box， HMGB）-1是否在眼组织中表达和释放，以及体内抑制HMGB-1是否可以通过内毒素抑制眼部炎症。诱导葡萄膜炎(EIU)。免疫组化研究显示，在EIU患者的角膜和虹膜中HMGB-1表达较高。诱导大鼠与对照大鼠比较。然而，HMGB-1的中和并不能减轻EIU患者的眼部炎症。这些结果提示，HMGB-1可能不参与eiu诱导大鼠血水屏障的破坏。

We investigated whether High Mobility Group Box(HMGB)-1 is expressed and released in ocular tissue and inhibition of HMGB-1 in vivo can suppress ocular inflammation using endotoxin. induced uveitis(EIU). Immunohistochemical study showed higher expression of HMGB-1 in cornea and iris in EIU. induced rats compared to control rats. However, neutralization of HMGB-1 was not able to reduce ocular inflammation in EIU. These results suggest that HMGB-1 may not be involved in the destruction of blood-aqueous barrier in EIU-induced rats.