Study for role of adhesin of periodontal pathogen in platelet aggregation

本研究的目的是阐明血管性血友病因子 A 结构域蛋白 (PGN0291)（牙龈卟啉单胞菌 Mfa1 菌毛的辅助蛋白）在血小板内聚集的功能。尽管未发现PGN0291蛋白与血小板聚集之间的关系，但获得了以下发现。 1. PGN0291蛋白是PGN0289和PGN0290的其他辅助蛋白的组装所必需的。 2.PGN0291蛋白参与牙龈卟啉单胞菌的自动聚集。 3. PGN0289蛋白定位于菌毛尖端。这些发现表明，Mfa1 菌毛的辅助蛋白 PGN0289、PGN0290 和 PGN0291 在尖端形成复合物，对 Mfa1 菌毛的功能很重要。

The aim of this study was to elucidate the function of von Willebrand factor A domainlike protein (PGN0291), the accessory protein of Mfa1 fimbriae of P. gingivalis, inplatelet aggregation. The following findings were obtained although relationshipbetween PGN0291 protein and platelet aggregation were not found. 1. PGN0291 proteinwas required for assembly of other accessory proteins of PGN0289 and PGN0290. 2.PGN0291 protein was involved in P. gingivalis auto-aggregation. 3. PGN0289 proteinwas localized at tip of fimbriae. These findings indicate that PGN0289, PGN0290 andPGN0291, the accessory proteins of Mfa1 fimbriae, form the complex at the tip, andare important for function of Mfa1 fimbriae.