Examination of the ASK1 involvement in a reactive oxygen spiecies-inducitive osteoclast activation signal.
Examination of the ASK1 involvement in a reactive oxygen spiecies-inducitive osteoclast activation signal.
批准号:
22791805
负责人:
KONDO Hisataka
金额:
$2.5万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2011
中文摘要
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英文摘要
It has been reported that reactive oxygen species is important for osteoclastogenesis and activation of apoptosis signal regulating kinase 1(ASK1). However, the role of ASK1 on osteoclastogenesis is still unknown. We investigated wheather ASK1 is involved in osteoclastogenesis and found that ASK1 involved in reactive oxygen spiecies-inducitive osteoclast activation.
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Continuous treatment with a low-dose β-agonist reduces bone mass by increasing bone resorption wighout suppressing bone formation
低剂量β-激动剂持续治疗通过增加骨吸收而不抑制骨形成来减少骨量
DOI:
--
发表时间:
2010
期刊:
Calcified Tissue International
影响因子:
4.2
作者:
[Kondo H, Togari A.]
通讯作者:
Togari A.
Comparison of ss-adrenergic and glucocorticoid signaling on clock gene and osteoblast-related gene expressions in human osteoblast
ss-肾上腺素能和糖皮质激素信号对人成骨细胞时钟基因和成骨细胞相关基因表达的比较
DOI:
--
发表时间:
2012
期刊:
Chronobiology International
影响因子:
2.8
作者:
[Komoto S, Kondo H, Fukuta O, Togari A]
通讯作者:
Togari A
交感神経活動はROSを介し破骨細胞分化を促進する
交感神经活动通过ROS促进破骨细胞分化
DOI:
--
发表时间:
2010
期刊:
影响因子:
--
作者:
[近藤久貴, 戸苅彰史, 近藤久貴, 近藤久貴, 近藤久貴]
通讯作者:
近藤久貴
DOI:
10.3109/07420528.2011.636496
发表时间:
2012-01-01
期刊:
CHRONOBIOLOGY INTERNATIONAL
影响因子:
2.8
作者:
[Komoto, Shintaro, Kondo, Hisataka, Togari, Akifumi]
通讯作者:
Togari, Akifumi
Continuous treatment with a low-dose β-agonist reduces bone mass by increasing bone resorption wighout suppressing bone formation.
持续使用低剂量β-激动剂治疗可通过增加骨吸收而不抑制骨形成来减少骨量。
DOI:
--
发表时间:
2010
期刊:
Calcified Tissue International
影响因子:
4.2
作者:
[Hisataka Kondo, Akifumi Togari]
通讯作者:
Akifumi Togari
共 12 条
To elcidalate the mechanisms of reactive oxygen spiecis regulats osteoclastogenesis
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批准号:20890249
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项目类别:Grant-in-Aid for Young Scientists (Start-up)
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资助金额:$1.95万
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财政年份:2008
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负责人:KONDO Hisataka
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依托单位:
海外基金