Identification of the key genes promoting angiogenesis and the signaling pathways regulating angiogenesis of the periodontal ligament derived stem cells

我们之前已经证明牙周韧带干细胞具有构建血管结构的潜力。当时，我们在同一来源中建立了两种类型的细胞，一种具有高血管生成能力，另一种具有低血管生成能力。这一次，我们比较了两种细胞的综合基因组表达谱。因此，我们已经能够选择几个有可能调节血管生成活性的候选基因。此外，通过利用具有高血管生成能力的细胞类型进一步研究血管生成表型，我们发现这些细胞可能不仅具有向血管组成细胞分化的能力，同时也具有向嗜酸性血细胞样细胞分化的能力。

We previously demonstrated that periodontal ligament derived stem cells have the potential to construct blood vessel structures. At that time, we have established two types of cells in a same origin, one has high angiogenic capacity and the other has low. And this time, we compared the comprehensive genomic expression profiles between the two types of cells. As a results, we have been able to select several candidate genes that have the possibility to regulate angiogenic activity. In addition, by further investigation about angiogenic phenotype using the cell type of possessing high angiogenic ability, we found the possibility that these cells have the ability to differentiate not only into blood vessel composed cells but also into eosinophilic blood cell-like cells simultaneously.